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KMID : 0352519830200010021
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Korea Univercity Medical Journal
1983 Volume.20 No. 1 p.21 ~ p.26
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Laboratory infections with Hantaan virus, the etiologic agent of hemorrhagic fever with renal syndrome
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Na Byoung-Man
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Abstract
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Nine clinically apparent infections with Hantaan virus, the etiologic agent of hemorrhagic fever with renal syndrone, occurred in persons exposed to the virus at the Virus Institute, Korea University, between 1971 and 1979. All directly related to trapping of wile rodents or work with naturally of experimentally infected wild and laboratory rodents a designated animal suite. All persons working in this environment, as well as two casual visitors, eventually become infected, whereas seven persons working with infected animal tissues and cell cultures in another building during this long interval exhibited neither clinical or subclinical manifestations of Hantaan virus infection.
All infections were acquired during the months of November to April, and none were associated with accidental parenteral inoculations, suggesting that aerosols produced by chronically infected rodents were the infectious vehicles and that limited air circulation and lowered humidity in the animal rooms during winter months increased the probability of virus transmission.
Five infections were clinically mild febrile episodes of five days or less and did not require hospitalization. Four other patients were treated in a hospital for 2-8 weeks; peritoneal dialysis was required to manage acute renal failure in three of these individuals. Four persons, inclnding two casual visitors, became ill within four months after initiation of experimental studies of Wistar rats with Hantaan virus, suggesting that this may be a highly infectious host for Hantaan virus.
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